Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 8/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8576115 | 0.82 | PDE4B (0.53) | HDAC1HDAC2PDE4BRECQLMEN1 | |
| SCHEMBL7326412 | 0.79 | HDAC1 (0.58) | HDAC1HDAC2PDE4BRECQLMEN1 | |
| SCHEMBL7323520 | 0.78 | PDE4B (0.54) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL8157358 | 0.77 | HDAC1 (0.56) | HDAC1HDAC2PDE4BRECQLMEN1 | |
| SCHEMBL7324348 | 0.77 | PDE4B (0.56) | HDAC1HDAC2PDE4BMEN1KMT2A | |
| SCHEMBL7335293 | 0.77 | PDE4A (0.58) | HDAC1HDAC2PDE4BMEN1KMT2A | |
| SCHEMBL5610571 | 0.77 | RECQL (0.61) | HDAC1HDAC2PDE4BRECQLPDE4A | |
| SCHEMBL7420826 | 0.76 | PDE4A (0.57) | HDAC1HDAC2PDE4BMEN1KMT2A | |
| SCHEMBL3170776 | 0.76 | PDE4B (0.53) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL7327718 | 0.75 | HDAC1 (0.59) | HDAC1HDAC2PDE4BRECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6051718-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AND A CYTOKINE ANTAGONIST FOR TREATING ALLERGIC, ATOPIC AND INFLAMMATORY DISEASES INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-04-18 | — | — | US | disclosed |