Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.58 |
| ▸ | F7 | P08709 | 9/20 | 0.58 |
| ▸ | F10 | P00742 | 8/20 | 0.54 |
| ▸ | TMPRSS6 | Q8IU80 | 9/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7148076 | 0.91 | F2 (0.70) | F2PRSS1F7F10TMPRSS6 | |
| SCHEMBL7146538 | 0.89 | F2 (0.59) | F2PRSS1F7F10TMPRSS6 | |
| SCHEMBL7143067 | 0.88 | F2 (0.65) | F2PRSS1F7F10TMPRSS6 | |
| Acetic Acid SCHEMBL8124396 | 0.86 | F2 (0.63) | F2PRSS1F7F10TMPRSS6 | |
| SCHEMBL8128137 | 0.79 | F7 (0.66) | F2PRSS1F7F10PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7146231 | 0.79 | F2 (0.65) | F2PRSS1F7F10TMPRSS6 | |
| Hydrochloric Acid SCHEMBL8127918 | 0.79 | F2 (0.70) | F2PRSS1F7F10PRSS2 | |
| Hydrochloric Acid SCHEMBL8127926 | 0.79 | F2 (0.70) | F2PRSS1F7F10PRSS2 | |
| Hydrochloric Acid SCHEMBL7150362 | 0.79 | F2 (0.70) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL8124400 | 0.78 | F2 (0.65) | F2PRSS1F7F10TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |