Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.70 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.70 |
| ▸ | F7 | P08709 | 11/20 | 0.70 |
| ▸ | F10 | P00742 | 10/20 | 0.64 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.53 |
| ▸ | F3 | P13726 | 2/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.53 |
| ▸ | TMPRSS6 | Q8IU80 | 8/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7146532 | 0.91 | F2 (0.58) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7146538 | 0.90 | F2 (0.59) | F2PRSS1F7F10PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7146231 | 0.89 | F2 (0.65) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7142896 | 0.88 | F2 (0.78) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7145102 | 0.88 | F2 (0.63) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL5883418 | 0.87 | F7 (0.68) | F2PRSS1F7F10PRSS2 | |
| Acetic Acid SCHEMBL8127149 | 0.87 | F2 (0.76) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7140785 | 0.85 | F7 (0.73) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7140792 | 0.85 | F7 (0.73) | F2PRSS1F7F10PRSS2 | |
| Acetic Acid SCHEMBL8114466 | 0.84 | F7 (0.72) | F2PRSS1F7F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |