Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 2/20 | 0.51 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.36 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407311 | 1.00 | ECE1 (0.51) | ECE1PLA2G4APLA2G6DPP4DPP7 | |
| SCHEMBL5404278 | 0.89 | ECE1 (0.51) | ECE1PLA2G4APLA2G6DPP4 | |
| SCHEMBL5415467 | 0.89 | ECE1 (0.51) | ECE1PLA2G4APLA2G6DPP4DPP7 | |
| SCHEMBL5407100 | 0.89 | ECE1 (0.47) | ECE1PLA2G4APLA2G6DPP4DPP7 | |
| SCHEMBL5407104 | 0.89 | ECE1 (0.47) | ECE1PLA2G4APLA2G6DPP4DPP7 | |
| SCHEMBL5413340 | 0.88 | ECE1 (0.60) | ECE1PLA2G4APLA2G6 | |
| SCHEMBL5409405 | 0.86 | ECE1 (0.45) | ECE1PLA2G4APLA2G6 | |
| SCHEMBL5403789 | 0.86 | ECE1 (0.48) | ECE1PLA2G4APLA2G6DPP4 | |
| SCHEMBL7148707 | 0.84 | ECE1 (0.44) | ECE1PLA2G4APLA2G6CYP2D6 | |
| SCHEMBL5400964 | 0.84 | ECE1 (0.44) | ECE1PLA2G4APLA2G6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |