Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.65 |
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | EGFR | P00533 | 8/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.54 |
| ▸ | FLT1 | P17948 | 6/20 | 0.54 |
| ▸ | FLT4 | P35916 | 6/20 | 0.54 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848480 | 0.85 | RET (0.70) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7147819 | 0.81 | KDR (0.66) | SRCKDREGFRFGFR1FLT1 | |
| SCHEMBL3674907 | 0.81 | SRC (0.86) | SRCKDREGFRFGFR1FLT1 | |
| SCHEMBL3673200 | 0.80 | EGFR (0.69) | SRCKDREGFRFGFR1FLT1 | |
| SCHEMBL3730315 | 0.80 | SRC (0.85) | SRCKDREGFRFGFR1FLT1 | |
| SCHEMBL3680459 | 0.80 | SRC (0.85) | SRCKDREGFRFGFR1FLT1 | |
| SCHEMBL6881994 | 0.80 | SRC (0.67) | SRCKDREGFRRET | |
| SCHEMBL6882002 | 0.80 | SRC (0.67) | SRCKDREGFRRET | |
| SCHEMBL7148463 | 0.79 | KDR (0.56) | SRCKDREGFRFGFR1FLT1 | |
| SCHEMBL7150412 | 0.79 | KDR (0.56) | SRCKDREGFRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332141-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2003-08-06 | — | — | EP | claimed |
| WO-2002034744-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-05-02 | — | — | WO | claimed |
| EP-1332141-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002034744-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-05-02 | — | — | WO | disclosed |