Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | EGFR | P00533 | 9/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.56 |
| ▸ | FLT1 | P17948 | 7/20 | 0.56 |
| ▸ | FLT4 | P35916 | 7/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 6/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148463 | 0.88 | KDR (0.56) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7140673 | 0.82 | KDR (0.57) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7147819 | 0.80 | KDR (0.66) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3680124 | 0.80 | KDR (0.64) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3679331 | 0.79 | KDR (0.65) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3677632 | 0.79 | KDR (0.63) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3671971 | 0.79 | EGFR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7146877 | 0.79 | SRC (0.65) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7252484 | 0.79 | KDR (0.66) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL3674169 | 0.79 | SRC (0.73) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326859-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2003-07-16 | — | — | EP | claimed |
| WO-2002030924-A9 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2003-05-22 | — | — | WO | claimed |
| WO-2002030924-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2002-04-18 | — | — | WO | claimed |
| EP-1326859-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030924-A9 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2003-05-22 | — | — | WO | disclosed |
| WO-2002030924-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2002-04-18 | — | — | WO | disclosed |