Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144535 | 0.91 | NTRK1 (0.40) | NTRK1PIM1ACVR1TUBB4ATUBB | |
| SCHEMBL7043074 | 0.91 | NTRK1 (0.45) | NTRK1PIM1CASP1KDM4EMEN1 | |
| SCHEMBL7041861 | 0.89 | IKBKB (0.46) | NTRK1PIM1KDM4EMEN1KMT2A | |
| SCHEMBL7143148 | 0.88 | NTRK1 (0.34) | NTRK1PIM1ACVR1CASP1KDM4E | |
| SCHEMBL7146568 | 0.88 | IKBKB (0.38) | KDM4EMEN1KMT2ATUBB4ATUBB | |
| SCHEMBL7148119 | 0.83 | IKBKB (0.38) | KDM4EMEN1KMT2ATUBB4ATUBB | |
| SCHEMBL7043840 | 0.83 | PARP1 (0.43) | KDM4ELMNASMN1; SMN2IKBKBMAPT | |
| SCHEMBL6875678 | 0.83 | IKBKB (0.35) | KDM4EMEN1KMT2ATUBB4ATUBB | |
| SCHEMBL7145673 | 0.83 | TLR8 (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7046810 | 0.82 | KDM4E (0.34) | CASP1KDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |