Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075777 | 1.00 | CTSS (0.44) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL6835198 | 1.00 | CTSS (0.44) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL5060017 | 1.00 | CTSS (0.44) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL5064260 | 1.00 | CTSS (0.44) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL5055741 | 1.00 | CTSS (0.44) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL5064577 | 1.00 | CTSS (0.44) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL27603663 | 0.90 | CTSS (0.47) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL5059303 | 0.89 | MEN1 (0.43) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL27713373 | 0.89 | MEN1 (0.43) | CTSSCTSKTSHRMEN1KMT2A | |
| SCHEMBL4187135 | 0.89 | KLK5 (0.49) | CTSSCTSKMEN1KMT2AKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268455-A2 | PIPERAZINE DERIVATIVES | Pfizer Products Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072728-A2 | NOVEL PIPERAZINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2001-10-04 | — | — | WO | disclosed |