Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | F13A1 | P00488 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | TGM1 | P22735 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.31 |
| ▸ | CLK1 | P49759 | 3/20 | 0.31 |
| ▸ | CLK3 | P49761 | 3/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.31 |
| ▸ | MAP3K19 | Q56UN5 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749766 | 0.89 | HDAC6 (0.40) | HDAC6MAPTHSD17B10CSNK1ECLK1 | |
| SCHEMBL6749761 | 0.89 | HDAC6 (0.40) | HDAC6MAPTHSD17B10CSNK1ECLK1 | |
| SCHEMBL6751888 | 0.84 | ICAM1 (0.43) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6751892 | 0.84 | ICAM1 (0.43) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6751926 | 0.84 | HDAC6 (0.38) | HDAC6 | |
| SCHEMBL6747458 | 0.83 | HDAC6 (0.40) | HDAC6MAPTHSD17B10CSNK1ECLK1 | |
| SCHEMBL6747374 | 0.82 | CYP4F2 (0.39) | HDAC6 | |
| SCHEMBL7147037 | 0.80 | HDAC6 (0.38) | HDAC6MAPTHSD17B10CSNK1ECLK1 | |
| SCHEMBL6745730 | 0.79 | HDAC6 (0.43) | HDAC6MAPTHSD17B10ALDH1A1MEN1 | |
| SCHEMBL6749064 | 0.79 | HDAC6 (0.41) | HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |