Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18911313 | 0.88 | PDE10A (0.49) | PDE10AKDM4EALDH1A1HPGDJAK2 | |
| SCHEMBL11417905 | 0.83 | PDE10A (0.45) | PDE10AKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL11413826 | 0.82 | PDE10A (0.44) | PDE10AKDM4EALDH1A1HPGDJAK2 | |
| SCHEMBL11410227 | 0.82 | PDE10A (0.47) | PDE10AKDM4EALDH1A1HPGDJAK2 | |
| SCHEMBL10271750 | 0.81 | JAK2 (0.46) | PDE10AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL14352211 | 0.78 | PDE10A (0.46) | PDE10AKDM4EALDH1A1HPGDJAK2 | |
| SCHEMBL2717765 | 0.74 | JAK2 (0.46) | PDE10AKDM4EALDH1A1HPGDJAK2 | |
| SCHEMBL10277904 | 0.74 | JAK2 (0.46) | PDE10AKDM4EALDH1A1HPGDJAK2 | |
| SCHEMBL14736721 | 0.74 | JAK2 (0.46) | PDE10AKDM4EALDH1A1HPGDJAK2 | |
| SCHEMBL21835232 | 0.72 | KDM4E (0.39) | PDE10AKDM4EALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972774-B1 | 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-a)pyridines | DOW AGROSCIENCES LLC (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-0972774-A3 | 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines | Dow AgroSciences LLC (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0972774-A2 | 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines | Dow AgroSciences LLC (US) | 2000-01-19 | — | — | EP | disclosed |