Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835405 | 0.79 | ADORA3 (0.38) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL21835404 | 0.77 | TYR (0.37) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7147342 | 0.72 | PDE10A (0.46) | KDM4EALDH1A1SMN1; SMN2CYP3A4LMNA | |
| SCHEMBL31257450 | 0.72 | AHR (0.34) | KDM4EALDH1A1GAAMAPTPDE10A | |
| SCHEMBL24222029 | 0.71 | AOC3 (0.44) | — | |
| SCHEMBL21835396 | 0.71 | TYR (0.40) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL21835387 | 0.70 | KDM4E (0.43) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7533737 | 0.69 | ALDH1A1 (0.45) | KDM4EALDH1A1KMT2ACYP3A4PDE10A | |
| SCHEMBL20641321 | 0.68 | PIK3CG (0.44) | — | |
| SCHEMBL31456654 | 0.68 | AHR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037334-B2 | Inhibitors of VAP-1 | ACUCELA INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037334-B2 | Inhibitors of VAP-1 | ACUCELA INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037334-B2 | Inhibitors of VAP-1 | ACUCELA INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-20220024915-A1 | INHIBITORS OF VAP-1 | ACUCELA INC. | 2022-01-27 | — | — | US | disclosed |
| US-20220024915-A1 | INHIBITORS OF VAP-1 | ACUCELA INC. | 2022-01-27 | — | — | US | disclosed |
| EP-3856194-A2 | INHIBITORS OF VAP-1 | Acucela, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| CN-113164489-A | Inhibitors of VAP-1 | 奥克塞拉有限公司 | 2021-07-23 | — | — | CN | disclosed |
| WO-2020069335-A2 | INHIBITORS OF VAP-1 | ACUCELA INC. (US) | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220024915-A1 | INHIBITORS OF VAP-1 | VAPB, VAPA, TOE1 | KDM4E 3383/4885ALDH1A1 869/4885MEN1 4691/4885 |
| US-12037334-B2 | Inhibitors of VAP-1 | VAPB, VAPA, TOE1 | KDM4E 3383/4885ALDH1A1 869/4885MEN1 4691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.