Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.52 |
| ▸ | F7 | P08709 | 8/20 | 0.52 |
| ▸ | F10 | P00742 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147539 | 1.00 | F2 (0.52) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL8128134 | 0.92 | F2 (0.52) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL5882666 | 0.91 | ALDH1A1 (0.47) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL7143883 | 0.90 | F2 (0.55) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL7150819 | 0.87 | F2 (0.70) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL7150813 | 0.87 | F2 (0.70) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL7146130 | 0.87 | F2 (0.57) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL7146126 | 0.87 | F2 (0.57) | F2PRSS1F7F10ALDH1A1 | |
| SCHEMBL7146545 | 0.87 | F2 (0.57) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7144098 | 0.86 | F2 (0.58) | F2PRSS1F7F10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |