SCHEMBL7147685

SCHEMBL7147685

CCCCOc1cc(C=O)cc(OC)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.64
MAOA P21397 3/20 0.48
MAOB P27338 3/20 0.48
FFAR1 O14842 1/20 0.48
PPARG P37231 1/20 0.48
PPARD Q03181 1/20 0.48
PPARA Q07869 1/20 0.48
ESR1 P03372 4/20 0.46
ALDH1A1 P00352 2/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CHRNA7 P36544 2/20 0.46
CHRNA10 Q9GZZ6 2/20 0.46
CHRNA9 Q9UGM1 2/20 0.46
CYP2A6 P11509 1/20 0.46
CHRNB2 P17787 1/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5883712 0.93 AHR (0.53) AHRPPARGALDH1A1LMNAMAPT
SCHEMBL24993379 0.91 AHR (0.53) AHRMAOAMAOBFFAR1PPARG
SCHEMBL16247012 0.89 SMN1; SMN2 (0.51) AHRPPARGALDH1A1LMNAMAPT
SCHEMBL22910274 0.87 PLA2G2A (0.54) AHRPPARGALDH1A1LMNAMAPT
SCHEMBL89112 0.86 AHR (0.47) AHRMAOAMAOBFFAR1PPARG
SCHEMBL10497527 0.86 PLA2G2A (0.57) AHRALDH1A1LMNAMAPTHPGD
SCHEMBL6851550 0.86 PLA2G2A (0.57) AHRALDH1A1LMNAMAPTHPGD
SCHEMBL6847389 0.86 PLA2G2A (0.57) AHRALDH1A1LMNAMAPTHPGD
SCHEMBL10497859 0.86 PLA2G2A (0.57) AHRALDH1A1LMNAMAPTHPGD
SCHEMBL10497885 0.86 PLA2G2A (0.57) AHRALDH1A1LMNAMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1115330-C N- (4-amidinophenyl) glycinamide derivatives HOFFMANN LA ROCHE (CH) 2003-07-23 CN disclosed
EP-0921116-B1 N-(4-carbamimido-phenyl)-glycine amide derivatives HOFFMANN LA ROCHE (CH) 2003-06-18 EP disclosed
US-6140353-A USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS HOFFMANN-LA ROCHE INC. (US) 2000-10-31 US disclosed
CN-1224714-A N- (4-amidinophenyl) glycinamide derivatives HOFFMANN LA ROCHE (CH) 1999-08-04 CN disclosed
EP-0921116-A1 N-(4-carbamimido-phenyl)-glycine amide derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-06-09 EP disclosed