Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 16/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038824 | 0.84 | LSS (0.39) | LSSKDM4EMEN1MAPTKMT2A | |
| SCHEMBL5038061 | 0.83 | LSS (0.44) | LSS | |
| SCHEMBL5040359 | 0.81 | LSS (0.44) | LSS | |
| SCHEMBL5038195 | 0.80 | LSS (0.41) | LSS | |
| SCHEMBL5040357 | 0.79 | LSS (0.57) | LSS | |
| SCHEMBL5043263 | 0.78 | LSS (0.40) | LSSKDM4E | |
| SCHEMBL5040452 | 0.78 | LSS (0.48) | LSSKDM4EMAPTKMT2A | |
| SCHEMBL5038837 | 0.76 | LSS (0.45) | LSS | |
| SCHEMBL5040247 | 0.76 | NOS1 (0.60) | KDM4EKMT2A | |
| SCHEMBL5039047 | 0.75 | LSS (0.53) | LSSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |