Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 9/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 4/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409534 | 1.00 | ECE1 (0.45) | ECE1MMEACECA12CA1 | |
| SCHEMBL5406244 | 0.90 | ECE1 (0.46) | ECE1MMEACECCR4MCOLN3 | |
| SCHEMBL5412891 | 0.88 | ECE1 (0.44) | ECE1MMEACETPSAB1CCR4 | |
| SCHEMBL5410489 | 0.83 | ECE1 (0.48) | ECE1MMEACEMCOLN3ALDH1A1 | |
| SCHEMBL7139351 | 0.83 | ECE1 (0.48) | ECE1MMEACEMCOLN3ALDH1A1 | |
| SCHEMBL7142759 | 0.83 | ALDH1A1 (0.47) | ECE1MMEACECCR4ALDH1A1 | |
| SCHEMBL7137948 | 0.83 | ALDH1A1 (0.47) | ECE1MMEACECCR4ALDH1A1 | |
| SCHEMBL5401069 | 0.82 | ECE1 (0.50) | ECE1MMEACECCR4MCOLN3 | |
| SCHEMBL7140964 | 0.82 | ECE1 (0.46) | ECE1MMEACEMCOLN3ALDH1A1 | |
| SCHEMBL7144246 | 0.82 | ECE1 (0.48) | ECE1MMEACECCR4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |