Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338768 | 0.98 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL7334762 | 0.98 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL4828609 | 0.98 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL7333008 | 0.98 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL27536116 | 0.94 | DRD4 (0.47) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL5841721 | 0.94 | L3MBTL1 (0.53) | KDM4EMEN1MAPTKMT2AATM | |
| SCHEMBL6132620 | 0.92 | ATM (0.51) | KDM4EATML3MBTL1DRD4DRD2 | |
| SCHEMBL6753836 | 0.92 | ATM (0.51) | KDM4EATML3MBTL1DRD4DRD2 | |
| SCHEMBL6132633 | 0.92 | ATM (0.51) | KDM4EATML3MBTL1DRD4DRD2 | |
| SCHEMBL6132362 | 0.92 | ATM (0.51) | KDM4EATML3MBTL1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1261429-C | Cholesterol lowering benzo [ b ] thiophenes and benzo [ d ] isothiazoles | HOFFMANN LA ROCHE (CH) | 2006-06-28 | — | — | CN | disclosed |
| CN-1471522-A | Cholesterol lowering benzo [b] thiophenes and benzo[d] isothiazoles | - | 2004-01-28 | — | — | CN | disclosed |
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |