SCHEMBL7148148

SCHEMBL7148148

CC(Br)C1=CCc2ccccc21

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CES1 P23141 1/20 0.30
MAOA P21397 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11769273 0.85 HTR6 (0.33) HTR6CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6626052 0.83 HTR6 (0.37) HTR6CES1MAOA
SCHEMBL5702808 0.83 PTPN1 (0.39) HTR6CES1MAOA
SCHEMBL30084467 0.83 PTPN1 (0.39) HTR6CES1MAOA
SCHEMBL27547777 0.80 HTR6 (0.35) HTR6CES1MAOA
SCHEMBL30084478 0.77 CHRM2 (0.41) HTR6CYP2D6HSD17B10
SCHEMBL20996203 0.77 CHRM2 (0.41) HTR6CYP2D6HSD17B10
SCHEMBL20996272 0.77 TSHR (0.41) HTR6
SCHEMBL30084546 0.77 TSHR (0.41) HTR6
SCHEMBL11772381 0.77 HTR6 (0.33) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030036612-A1 Hetero cyclic metallocene compounds and use thereof in catalyst system for producing olefin polymers BASELL POLYOLEFINE GMBH (DE) 2003-02-20 US disclosed
EP-1157027-A1 HETEROCYCLIC METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS Basell Technology Company B.V. (NL) 2001-11-28 EP disclosed
WO-2001047939-A1 HETEROCYCLIC METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-05 WO disclosed