Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.45 |
| ▸ | PDE4A | P27815 | 10/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148139 | 0.84 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CRECQL | |
| SCHEMBL7148144 | 0.84 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CRECQL | |
| SCHEMBL7144832 | 0.83 | PDE4B (0.42) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7146095 | 0.76 | PDE4B (0.49) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7415859 | 0.75 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CRECQL | |
| SCHEMBL9275919 | 0.74 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4CRECQL | |
| SCHEMBL7145904 | 0.73 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7415851 | 0.71 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CRECQL | |
| SCHEMBL7415853 | 0.71 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CRECQL | |
| SCHEMBL7147618 | 0.71 | PDE4B (0.50) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6051718-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AND A CYTOKINE ANTAGONIST FOR TREATING ALLERGIC, ATOPIC AND INFLAMMATORY DISEASES INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-04-18 | — | — | US | disclosed |