Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.43 |
| ▸ | PDE4A | P27815 | 14/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382243 | 0.84 | PDE4B (0.42) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL7415853 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CRECQL | |
| SCHEMBL7415851 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CRECQL | |
| SCHEMBL7379529 | 0.77 | PDE4B (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7148155 | 0.75 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CRECQL | |
| SCHEMBL7381457 | 0.74 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7148139 | 0.72 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CRECQL | |
| SCHEMBL7148144 | 0.72 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CRECQL | |
| SCHEMBL7380185 | 0.71 | PDE4B (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7145897 | 0.71 | HDAC1 (0.48) | PDE4DPDE4APDE4BPDE4CRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998014432-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-04-09 | — | — | WO | disclosed |