Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.46 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089309 | 0.88 | MAPT (0.46) | GSK3BTNNI3TNNT2TNNC1MKNK1 | |
| SCHEMBL5100095 | 0.85 | MAPT (0.48) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL5089316 | 0.83 | GSK3B (0.48) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL6085675 | 0.83 | MAPT (0.47) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL27559775 | 0.81 | GSK3B (0.48) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL7027680 | 0.81 | GSK3B (0.49) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL7021102 | 0.80 | GSK3B (0.46) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL7026103 | 0.80 | GSK3B (0.45) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL5093412 | 0.79 | GSK3B (0.57) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 | |
| SCHEMBL5100625 | 0.79 | DPP4 (0.49) | GSK3BMKNK1MKNK2POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |