Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089586 | 0.88 | MAPT (0.45) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL5089316 | 0.83 | GSK3B (0.48) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL7249883 | 0.82 | GSK3B (0.54) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL7249886 | 0.81 | GSK3B (0.73) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL5100095 | 0.81 | MAPT (0.48) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL7148207 | 0.81 | GSK3B (0.46) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL5093412 | 0.80 | GSK3B (0.57) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL27559775 | 0.80 | GSK3B (0.48) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL7026103 | 0.79 | GSK3B (0.45) | GSK3BDPP4MKNK1MKNK2MEN1 | |
| SCHEMBL6085675 | 0.79 | MAPT (0.47) | GSK3BDPP4MKNK1MKNK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |