Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.52 |
| ▸ | CTSS | P25774 | 17/20 | 0.49 |
| ▸ | CTSL | P07711 | 15/20 | 0.49 |
| ▸ | CTSV | O60911 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 10/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13677296 | 1.00 | CTSK (0.52) | CTSKCTSSCTSLCTSVCTSB | |
| SCHEMBL4451293 | 1.00 | CTSK (0.52) | CTSKCTSSCTSLCTSVCTSB | |
| SCHEMBL5941652 | 0.78 | CTSK (0.59) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4218209 | 0.78 | CTSK (0.59) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4218204 | 0.78 | CTSK (0.59) | CTSKCTSSCTSLCTSB | |
| SCHEMBL13677172 | 0.78 | CTSK (0.79) | CTSKCTSSCTSLCTSV | |
| SCHEMBL4206106 | 0.77 | CTSK (0.52) | CTSKCTSSCTSLCTSV | |
| SCHEMBL4206111 | 0.77 | CTSK (0.52) | CTSKCTSSCTSLCTSV | |
| SCHEMBL7154653 | 0.77 | CTSK (0.64) | CTSKCTSSCTSLCTSV | |
| SCHEMBL4451492 | 0.77 | CTSK (0.64) | CTSKCTSSCTSLCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |