Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148319 | 0.80 | GSK3B (0.50) | CDK1GSK3AGSK3BIDO1PDE5A | |
| SCHEMBL6069053 | 0.70 | GSK3B (0.47) | CDK1GSK3AGSK3BIDO1CNR1 | |
| SCHEMBL5089665 | 0.68 | CDK1 (0.51) | CDK1GSK3AGSK3BIDO1CNR1 | |
| SCHEMBL6334824 | 0.67 | IDO1 (0.65) | IDO1CNR1CNR2MEN1KMT2A | |
| SCHEMBL29367195 | 0.67 | IDO1 (0.50) | CDK1GSK3AGSK3BIDO1CNR1 | |
| SCHEMBL5089661 | 0.67 | GSK3B (0.60) | CDK1GSK3AGSK3BIDO1PDE5A | |
| SCHEMBL5099510 | 0.65 | CNR1 (0.51) | CDK1GSK3AGSK3BIDO1PDE5A | |
| SCHEMBL27253612 | 0.65 | CDK1 (0.49) | CDK1GSK3AGSK3BIDO1CNR1 | |
| SCHEMBL6342180 | 0.65 | IDO1 (0.70) | IDO1MEN1KMT2AMAPK1NOTUM | |
| SCHEMBL27538053 | 0.65 | GSK3B (0.56) | CDK1GSK3AGSK3BIDO1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |