⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL9639746 | 0.95 | — | — | |
| Tetrahydrofuran SCHEMBL7863243 | 0.95 | ALDH1A1 (0.89) | — | |
| Tetrahydrofuran SCHEMBL22042165 | 0.95 | ALDH1A1 (0.89) | — | |
| Tetrahydrofuran SCHEMBL8932697 | 0.95 | — | — | |
| Tetrahydrofuran SCHEMBL28097459 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL22041982 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL7947123 | 0.90 | ALDH1A1 (0.80) | — | |
| SCHEMBL19210123 | 0.90 | — | — | |
| Hydrogen Sulfide SCHEMBL8064910 | 0.90 | ALDH1A1 (0.80) | — | |
| Hydrogen Sulfide SCHEMBL22117256 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030166896-A1 | Base-modified enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. | 2003-09-04 | — | — | US | disclosed |
| US-6528639-B2 | Active ribozyme | RIBOZYME PHARMACEUTICALS, INC. | 2003-03-04 | — | — | US | disclosed |
| US-20010006801-A1 | BASE-MODIFIED ENZYMATIC NUCLEIC ACID | USMAN NASSIM (US) | 2001-07-05 | — | — | US | disclosed |
| US-5891684-A | RIBOZYMES | RIBOZYME PHARMACEUTICALS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| US-5879938-A | RIBOZYME WITH INCREASED ACTIVITY BY SUBSTITUTION OF MODIFIED NUCLEOTIDE INTO SUBSTRATE BINDING ARM OR CATALYTIC CORE | RIBOZYME PHARMACEUTICALS, INC. (US) | 1999-03-09 | — | — | US | disclosed |
| US-5767263-A | Base-modified enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. (US) | 1998-06-16 | — | — | US | disclosed |
| US-5672511-A | Base-modified enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. (US) | 1997-09-30 | — | — | US | disclosed |
| US-5672501-A | Base-modified enzymatic nucleic acid | RIBOZYME PHARMACEUTICALS, INC. (US) | 1997-09-30 | — | — | US | disclosed |