SCHEMBL7148640

SCHEMBL7148640

CC1=C([Si](C)(C)NC(C)(C)C)c2c(ccc3ccccc23)C1

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 1/20 0.32
SALL4 Q9UJQ4 1/20 0.32
TRIM33 Q9UPN9 1/20 0.32
HTR6 P50406 1/20 0.31
MAPT P10636 1/20 0.31
NFKB1 P19838 2/20 0.30
NFKB2 Q00653 2/20 0.30
RELA Q04206 2/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2A6 P11509 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7169500 0.97 SALL4 (0.31) TRIM24SALL4TRIM33HTR6CYP2A6
Hydrochloric Acid SCHEMBL7165108 0.97 SALL4 (0.31) TRIM24SALL4TRIM33HTR6CYP2A6
SCHEMBL3199427 0.81 MAPT (0.37) MAPTCYP1A2CYP2A6TSHR
SCHEMBL7198080 0.76 NISCH (0.30)
Hydrochloric Acid SCHEMBL7169014 0.75 NISCH (0.34)
SCHEMBL9059241 0.72 MAPT (0.37) MAPTCYP1A2CYP2A6TSHR
Iodide SCHEMBL28815180 0.70 MAPT (0.38) MAPTCYP1A2CYP2A6TSHR
Bromide SCHEMBL28815167 0.70 MAPT (0.38) MAPTCYP1A2CYP2A6TSHR
Hydrochloric Acid SCHEMBL28815114 0.70 MAPT (0.38) MAPTCYP1A2CYP2A6TSHR
Hydrochloric Acid SCHEMBL7170194 0.68 MAPT (0.33) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1153032-B1 BIMETALLIC METALLOCENE CATALYST FOR ISOTACTIC POLYPROPYLENE POLYMERISATION ATOFINA RES (BE) 2003-04-02 EP claimed
US-6583243-B2 Addition polymerization using metallocene catalyst FINA RESEARCH, S.A. (BE) 2003-06-24 US disclosed
US-6579822-B2 Coordination polymerization catalyst FINA RESEARCH, S.A. (BE) 2003-06-17 US disclosed
EP-1153032-B1 BIMETALLIC METALLOCENE CATALYST FOR ISOTACTIC POLYPROPYLENE POLYMERISATION ATOFINA RES (BE) 2003-04-02 EP disclosed
US-20020133034-A1 Polyolefin production RAZAVI ABBAS (BE) 2002-09-19 US disclosed
US-20020120161-A1 Polyolefin production RAZAVI ABBAS (BE) 2002-08-29 US disclosed
US-6407273-B1 COORDINATION CATALYST FINA RESEARCH, S.A. (BE) 2002-06-18 US disclosed
EP-1010709-A1 Metallocene compound and its use for polyolefin production FINA RESEARCH S.A. (BE) 2000-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020133034-A1 Polyolefin production SRRM2, CSE1L, CACNA1A TRIM24 1089/4885SALL4 197/4885TRIM33 2929/4885
US-20020120161-A1 Polyolefin production SRRM2, CSE1L, CACNA1A TRIM24 998/4885SALL4 195/4885TRIM33 2723/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.