Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.52 |
| ▸ | DRD2 | P14416 | 18/20 | 0.42 |
| ▸ | HTR7 | P34969 | 18/20 | 0.42 |
| ▸ | HTR6 | P50406 | 18/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034985 | 0.94 | HTR1A (0.53) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL7030051 | 0.93 | HTR1A (0.61) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL7032693 | 0.91 | HTR1A (0.51) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL7004959 | 0.90 | HTR1A (0.54) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL6844238 | 0.89 | HTR1A (0.64) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL7034836 | 0.87 | HTR1A (0.49) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL6848226 | 0.82 | HTR1A (0.64) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL6847481 | 0.80 | HTR1A (0.78) | HTR1ASLC6A4DRD2HTR6HTR2A | |
| SCHEMBL6411310 | 0.80 | HTR1A (0.45) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL6843626 | 0.79 | HTR1A (0.61) | HTR1ASLC6A4DRD2HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392700-B1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 7,8-DIHYDRO-1,6,9-TRIOXA-3-AZA-CYCLOPENTA(A)NAPHTHALENE | WYETH CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6617334-B2 | Inhibiting the reuptake of serotonin in a subject suffering from postraumatic stress, ADD, premenstrual dysphoria, obesity, eating disorder, vasomotor flushing, cocaine and alcohol addiction, and sexual dysfunction | WYETH | 2003-09-09 | — | — | US | disclosed |
| US-6613913-B2 | Intermediate for antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1, 6,9-trioxa-3-aza-cyclopenta [a]naphthalene | WYETH | 2003-09-02 | — | — | US | disclosed |
| US-6525075-B2 | For therapy of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders | WYETH | 2003-02-25 | — | — | US | disclosed |