SCHEMBL7148728

SCHEMBL7148728

N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H](N)Cc2ccccc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F2 P00734 13/20 0.74
TMPRSS11D O60235 9/20 0.59
F10 P00742 2/20 0.58
PLG P00747 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15077024 1.00 F2 (0.74) F2TMPRSS11DF10PLG
SCHEMBL23752316 1.00 F2 (0.74) F2TMPRSS11DF10PLG
Hydrochloric Acid SCHEMBL7357933 0.99 F2 (0.73) F2TMPRSS11DF10PLG
Hydrochloric Acid SCHEMBL7147479 0.99 F2 (0.73) F2TMPRSS11DF10PLG
SCHEMBL23793876 0.94 F2 (0.65) F2TMPRSS11DF10PLG
SCHEMBL21067756 0.91 DPP4 (0.61) F2
SCHEMBL21067758 0.91 DPP4 (0.61) F2
SCHEMBL7102905 0.91 F2 (0.61) F2TMPRSS11D
Acetic Acid SCHEMBL6482237 0.90 F2 (0.76) F2TMPRSS11DF10PLG
SCHEMBL7460022 0.89 F2 (0.58) F2TMPRSS11D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1361212-A1 Peptide derivatives as antithrombotic agents AstraZeneca AB (SE) 2003-11-12 EP claimed
EP-0672658-A1 Antithrombotic agents ELI LILLY AND COMPANY (US) 1995-09-20 EP claimed
WO-1995023609-A1 ANTITHROMBOTIC AGENTS ELI LILLY AND COMPANY (US) 1995-09-08 WO claimed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed