Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | BACE1 | P56817 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 6/20 | 0.63 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471343 | 0.95 | MAPT (0.75) | MAPTTP53BACE1ESR1GAA | |
| SCHEMBL7023154 | 0.93 | MAPT (0.65) | MAPTTP53BACE1ESR1GAA | |
| SCHEMBL7097120 | 0.90 | MAPT (0.62) | MAPTTP53BACE1ESR1GAA | |
| SCHEMBL7624753 | 0.89 | MAPT (0.61) | MAPTTP53BACE1ESR1GAA | |
| SCHEMBL6244847 | 0.89 | KDM4E (0.66) | MAPTTP53ESR1GAAALDH1A1 | |
| SCHEMBL6530068 | 0.89 | MAPT (0.58) | MAPTTP53BACE1ESR1GAA | |
| SCHEMBL6234637 | 0.87 | MAPT (0.69) | MAPTTP53BACE1ESR1GAA | |
| SCHEMBL6243893 | 0.86 | MAPT (0.71) | MAPTTP53BACE1GAAALDH1A1 | |
| SCHEMBL6514955 | 0.84 | MAPT (0.71) | MAPTTP53BACE1GAAALDH1A1 | |
| SCHEMBL6510914 | 0.84 | KDM4E (0.65) | MAPTTP53BACE1ESR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |