Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471343 | 0.87 | MAPT (0.75) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7052320 | 0.87 | PTPN5 (0.55) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6239374 | 0.87 | MAPT (0.54) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7023154 | 0.87 | MAPT (0.65) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7148923 | 0.87 | MAPT (0.68) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7097120 | 0.84 | MAPT (0.62) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7624753 | 0.83 | MAPT (0.61) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7191192 | 0.78 | ALDH1A1 (0.60) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6239501 | 0.78 | MEN1 (0.56) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6218995 | 0.78 | MEN1 (0.54) | MAPTGAAKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531904-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB | Warner-Lambert Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004007024-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |