SCHEMBL7149097

SCHEMBL7149097

COc1ccc(Cc2ccc(CC(C)=O)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.59
SAE1 Q9UBE0 1/20 0.59
UBA2 Q9UBT2 1/20 0.59
POLB P06746 2/20 0.58
LTA4H P09960 1/20 0.57
SMN1; SMN2 Q16637 2/20 0.54
CTBP2 P56545 1/20 0.53
TDP1 Q9NUW8 2/20 0.51
KMT2A Q03164 2/20 0.51
ATM Q13315 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
PKM P14618 1/20 0.51
ALDH1A1 P00352 2/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C19 P33261 1/20 0.50
USP2 O75604 1/20 0.50
TP53 P04637 1/20 0.50
LDHA P00338 1/20 0.50
MEN1 O00255 1/20 0.50
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL48525 0.94 HTT (0.66) HTTPOLBSMN1; SMN2CTBP2KMT2A
SCHEMBL28709451 0.94 HTT (0.66) HTTPOLBSMN1; SMN2CTBP2KMT2A
SCHEMBL9262585 0.89 HTT (0.59) HTTPOLBLTA4HSMN1; SMN2CTBP2
SCHEMBL9417745 0.89 HTT (0.59) HTTPOLBSMN1; SMN2CTBP2KMT2A
SCHEMBL9468432 0.85 KDM4E (0.68) HTTSAE1UBA2POLBLTA4H
Propylene Glycol SCHEMBL29111692 0.84 POLB (0.62) HTTPOLBSMN1; SMN2CTBP2TDP1
SCHEMBL29111694 0.84 POLB (0.57) HTTPOLBSMN1; SMN2CTBP2TDP1
SCHEMBL11346487 0.84 HTT (0.54) HTTPOLBSMN1; SMN2CTBP2KMT2A
SCHEMBL18327985 0.82 HTT (0.53) HTTPOLBSMN1; SMN2CTBP2TDP1
SCHEMBL12895869 0.81 SMN1; SMN2 (0.57) HTTPOLBSMN1; SMN2KMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9365683-B2 Polycarbonate-polyorganosiloxane copolymer and method for producing same IDEMITSU KOSAN CO., LTD. (JP) 2016-06-14 US disclosed
US-20160017102-A1 POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER AND METHOD FOR PRODUCING SAME IDEMITSU KOSAN CO., LTD. (JP) 2016-01-21 US disclosed
US-20030143701-A1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. 2003-07-31 US disclosed
EP-0924194-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2003-05-14 EP disclosed
US-6528686-B1 Reacting primary amine and ketone functionalized derivatives; catalytically reducing DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2003-03-04 US disclosed
EP-0924193-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2003-02-19 EP disclosed
EP-0939134-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2002-09-11 EP disclosed
US-6114582-A DECYCLIZATION TO FORM A CHEMICAL INTERMEDIATE FOR PRODUCING AN ANTI-OBESITY AGENT AND ANTIDIABETIC AGENT DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2000-09-05 US disclosed
EP-0654534-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2000-03-01 EP disclosed
EP-0939134-A1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1999-09-01 EP disclosed
EP-0924194-A2 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1999-06-23 EP disclosed
EP-0924193-A1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1999-06-23 EP disclosed
US-5811293-A CULTURE PRODUCT AS CHEMICAL INTERMEDIATE FOR ANTI-OBESITY AGENT DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-22 US disclosed
US-5629200-A MICROORGANISM DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1997-05-13 US disclosed
EP-0654534-A2 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1995-05-24 EP disclosed