Sugi Predict

Sugi Predict / Compounds / SCHEMBL7149146

SCHEMBL7149146

SCHEMBL7149146

Cc1cc(SC(C)(C)c2cnc(-c3ccc(C(F)(F)F)cc3)s2)ccc1OC(C)(C)C(=O)O.Cc1cc(SC(C)(C)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OC(C)(C)C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PPARD Q03181 20/20 0.55
▸ PPARA Q07869 14/20 0.55
▸ PPARG P37231 6/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7149152 0.93 PPARD (0.47) PPARDPPARAPPARG
SCHEMBL4830259 0.93 PPARD (0.59) PPARDPPARAPPARG
SCHEMBL4830507 0.93 PPARD (0.62) PPARDPPARAPPARG
SCHEMBL7109172 0.92 PPARD (0.48) PPARDPPARAPPARG
SCHEMBL4827146 0.85 PPARD (0.51) PPARDPPARAPPARG
SCHEMBL4830243 0.84 PPARD (0.53) PPARDPPARAPPARG
SCHEMBL4823106 0.77 PPARD (0.56) PPARDPPARAPPARG
SCHEMBL4823495 0.77 PPARA (0.63) PPARDPPARAPPARG
SCHEMBL4830330 0.76 PPARD (0.58) PPARDPPARAPPARG
SCHEMBL4832067 0.76 PPARD (0.62) PPARDPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1343773-A1 THIAZOLE DERIVATIVES FOR TRAEING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2003-09-17 — — EP claimed
WO-2002062774-A1 THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2002-08-15 — — WO claimed
EP-1343773-A1 THIAZOLE DERIVATIVES FOR TRAEING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2003-09-17 — — EP disclosed
WO-2002062774-A1 THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2002-08-15 — — WO disclosed