Sugi Predict

Sugi Predict / Compounds / SCHEMBL7149152

SCHEMBL7149152

SCHEMBL7149152

Cc1cc(SC(C)(C)c2cnc(-c3ccc(C(F)(F)F)cc3)s2)ccc1OC(C)(C)C(=O)OC(=O)C(C)(C)Oc1ccc(SC(C)(C)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PPARD Q03181 20/20 0.47
▸ PPARA Q07869 11/20 0.47
▸ PPARG P37231 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7109172 0.94 PPARD (0.48) PPARDPPARAPPARG
SCHEMBL7149146 0.93 PPARD (0.55) PPARDPPARAPPARG
SCHEMBL4827146 0.87 PPARD (0.51) PPARDPPARAPPARG
SCHEMBL4830243 0.86 PPARD (0.53) PPARDPPARAPPARG
SCHEMBL4830259 0.85 PPARD (0.59) PPARDPPARAPPARG
SCHEMBL4830507 0.85 PPARD (0.62) PPARDPPARAPPARG
SCHEMBL7166428 0.75 PPARD (0.46) PPARDPPARAPPARG
SCHEMBL4831871 0.72 PPARD (0.53) PPARDPPARAPPARG
SCHEMBL4826456 0.72 PPARD (0.47) PPARDPPARAPPARG
SCHEMBL4831713 0.71 PPARD (0.60) PPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1343773-A1 THIAZOLE DERIVATIVES FOR TRAEING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2003-09-17 — — EP claimed
WO-2002062774-A1 THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2002-08-15 — — WO claimed
EP-1343773-A1 THIAZOLE DERIVATIVES FOR TRAEING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2003-09-17 — — EP disclosed
WO-2002062774-A1 THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2002-08-15 — — WO disclosed