Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235392 | 0.82 | MEN1 (0.54) | ESR1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL6260663 | 0.80 | ESR1 (0.56) | ESR1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6245178 | 0.80 | ESR1 (0.53) | ESR1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6259249 | 0.78 | KDM4E (0.55) | ESR1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7624469 | 0.78 | MEN1 (0.50) | ESR1MAPTALDH1A1KDM4EHTT | |
| SCHEMBL6471343 | 0.77 | MAPT (0.75) | ESR1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6218995 | 0.77 | MEN1 (0.54) | ESR1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL6239501 | 0.77 | MEN1 (0.56) | ESR1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL6466931 | 0.75 | MEN1 (0.54) | ESR1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL6464574 | 0.75 | MEN1 (0.46) | ESR1MAPTALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |