Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149827 | 0.84 | PTGS2 (0.43) | NPC1RAB9APTGS2PTGS1ADRA2A | |
| SCHEMBL7152138 | 0.83 | PTGS2 (0.43) | PTGS2PTGS1ADRA2AADRA2BADRA2C | |
| SCHEMBL213434 | 0.83 | PTGS2 (0.62) | KDM4ENPC1RAB9ASMN1; SMN2PTGS2 | |
| SCHEMBL6095275 | 0.83 | PTGS2 (0.62) | KDM4ENPC1RAB9ASMN1; SMN2PTGS2 | |
| SCHEMBL7146261 | 0.79 | PTGS2 (0.53) | PTGS2PTGS1ADRA2AADRA2BADRA2C | |
| SCHEMBL7146217 | 0.79 | PTGS2 (0.44) | PTGS2PTGS1ADRA2AADRA2BADRA2C | |
| SCHEMBL6093319 | 0.79 | PTGS2 (0.54) | KDM4ENPC1RAB9ASMN1; SMN2PTGS2 | |
| SCHEMBL7142073 | 0.79 | PTGS2 (0.41) | PTGS2PTGS1ADRA2AADRA2BADRA2C | |
| SCHEMBL7147955 | 0.79 | PTGS2 (0.42) | PTGS2PTGS1ADRA2AADRA2BADRA2C | |
| SCHEMBL7143134 | 0.78 | P2RY6 (0.50) | KDM4EPTGS2PTGS1P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977748-B1 | SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2003-03-26 | — | — | EP | claimed |