Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.50 |
| ▸ | F7 | P08709 | 4/20 | 0.50 |
| ▸ | F10 | P00742 | 4/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149300 | 1.00 | F2 (0.50) | F2PRSS1F7F10KEAP1 | |
| SCHEMBL7142561 | 0.91 | F2 (0.60) | F2PRSS1F7F10KEAP1 | |
| SCHEMBL7142566 | 0.91 | F2 (0.60) | F2PRSS1F7F10KEAP1 | |
| Acetic Acid SCHEMBL8120279 | 0.90 | F2 (0.59) | F2PRSS1F7F10KEAP1 | |
| SCHEMBL7149769 | 0.86 | F2 (0.46) | F2PRSS1F7F10HDAC8 | |
| SCHEMBL7142453 | 0.85 | F7 (0.66) | F2PRSS1F7F10NAMPT | |
| SCHEMBL7148118 | 0.81 | F2 (0.51) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7148395 | 0.79 | F7 (0.56) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7148405 | 0.79 | F7 (0.56) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL7148384 | 0.79 | F7 (0.56) | F2PRSS1F7F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |