Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 6/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035549 | 0.82 | LSS (0.58) | LSSMAOAMAOBMEN1LMNA | |
| SCHEMBL7142592 | 0.82 | LSS (0.52) | LSSMAOAMAOB | |
| SCHEMBL5038084 | 0.82 | LSS (0.59) | LSSMAOAMAOBMEN1MAPT | |
| SCHEMBL8485500 | 0.81 | LSS (0.61) | LSSMAOAMAOBMEN1MAPT | |
| SCHEMBL7146473 | 0.80 | LSS (0.41) | LSSITGB3ITGA2B | |
| SCHEMBL5140396 | 0.79 | LSS (0.64) | LSSMAPTKMT2A | |
| SCHEMBL5035456 | 0.78 | LSS (0.52) | LSSMAOBMEN1KMT2A | |
| SCHEMBL5140362 | 0.78 | LSS (0.68) | LSSMAPTKMT2A | |
| SCHEMBL5038939 | 0.78 | LSS (0.54) | LSS | |
| SCHEMBL7151209 | 0.77 | ITGB3 (0.42) | LSSITGB3ITGA2BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |