Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.54 |
| ▸ | PDE4A | P27815 | 10/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146146 | 0.85 | PDE4D (0.54) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3170776 | 0.83 | PDE4B (0.53) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7360862 | 0.81 | PDE4D (0.54) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6609750 | 0.78 | PDE4B (0.44) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL6583627 | 0.78 | PDE4D (0.72) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7147675 | 0.77 | PDE4B (0.50) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1774371 | 0.76 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7353099 | 0.76 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL5704671 | 0.76 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1773367 | 0.76 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6051718-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AND A CYTOKINE ANTAGONIST FOR TREATING ALLERGIC, ATOPIC AND INFLAMMATORY DISEASES INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-04-18 | — | — | US | disclosed |
| EP-0934280-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998014432-A1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-04-09 | — | — | WO | disclosed |