Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.50 |
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359923 | 0.82 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DSLC6A4 | |
| SCHEMBL3170776 | 0.82 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7365094 | 0.82 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DSLC6A4 | |
| SCHEMBL6606602 | 0.79 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DSLC6A4 | |
| SCHEMBL77974 | 0.78 | CA2 (0.61) | PIK3CGHIF1ANPSR1 | |
| SCHEMBL7149759 | 0.77 | PDE4D (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7412691 | 0.77 | PDE4A (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6587617 | 0.77 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6585141 | 0.76 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DSLC6A4 | |
| SCHEMBL21328361 | 0.75 | CA2 (0.52) | PIK3CGHIF1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6051718-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AND A CYTOKINE ANTAGONIST FOR TREATING ALLERGIC, ATOPIC AND INFLAMMATORY DISEASES INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-04-18 | — | — | US | disclosed |
| EP-0247725-B1 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |