Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 9/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150712 | 0.89 | LSS (0.48) | LSSKDM1AMAOBPPARDPPARA | |
| SCHEMBL7149010 | 0.88 | LSS (0.59) | LSSKDM1AITGB3ITGA2BCHEK1 | |
| SCHEMBL7152745 | 0.88 | LSS (0.47) | LSSITGB3ITGA2BCHEK1CHEK2 | |
| SCHEMBL7150699 | 0.83 | LSS (0.46) | LSS | |
| SCHEMBL7145197 | 0.83 | LSS (0.57) | LSSKDM1AITGB3ITGA2B | |
| SCHEMBL7148486 | 0.81 | LSS (0.49) | LSSPPARDPPARA | |
| SCHEMBL5035448 | 0.81 | LSS (0.54) | LSSMAOBPPARDPPARA | |
| SCHEMBL7152838 | 0.80 | LSS (0.55) | LSSKDM1ACHEK1 | |
| SCHEMBL5039022 | 0.79 | LSS (0.58) | LSS | |
| SCHEMBL5045466 | 0.78 | LSS (0.64) | LSSMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |