Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.47 |
| ▸ | PDE4A | P27815 | 11/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.47 |
| ▸ | QPCT | Q16769 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144848 | 0.84 | PDE4A (0.41) | PDE4BPDE4DPDE4APDE4CQPCT | |
| SCHEMBL6606569 | 0.81 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL72368 | 0.80 | PDE4A (0.50) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7148127 | 0.79 | PDE4A (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6606739 | 0.76 | PDE4A (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL72957 | 0.76 | PDE4A (0.58) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL70423 | 0.75 | PDE4A (0.57) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6605575 | 0.73 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL21045697 | 0.71 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7361467 | 0.70 | MEN1 (0.58) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656959-B1 | PDE IV inhibiting pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-02 | — | — | US | disclosed |
| EP-1068194-B1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-11-05 | — | — | EP | disclosed |