Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HEXA | P06865 | 1/20 | 0.33 |
| ▸ | HEXB | P07686 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27542429 | 0.89 | ESR1 (0.38) | MAPTMEN1KMT2AALDH1A1ESR1 | |
| SCHEMBL5038605 | 0.86 | ESR1 (0.39) | ALDH1A1ESR1MAOBPPARGPPARD | |
| SCHEMBL27542384 | 0.86 | ESR1 (0.39) | MAPTMEN1KMT2AALDH1A1ESR1 | |
| SCHEMBL5039002 | 0.85 | ESR1 (0.33) | ESR1S1PR1 | |
| SCHEMBL5035391 | 0.85 | ESR1 (0.38) | MAPTMEN1KMT2AALDH1A1ESR1 | |
| SCHEMBL5039009 | 0.84 | MAOB (0.41) | ALDH1A1ESR1MAOBPPARGPPARD | |
| SCHEMBL5038256 | 0.81 | CHKA (0.43) | ALDH1A1ESR1KDM4EKCNH2 | |
| SCHEMBL5035374 | 0.81 | SIGMAR1 (0.44) | ALDH1A1ESR1KDM4EKCNH2 | |
| SCHEMBL5045382 | 0.81 | LSS (0.36) | ESR1KDM4ES1PR1KCNH2 | |
| SCHEMBL5035335 | 0.80 | ESR1 (0.35) | MAPTKMT2AESR1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |