Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154060 | 1.00 | HRH3 (0.46) | HRH3HTTSMN1; SMN2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4889879 | 0.99 | HRH3 (0.45) | HRH3HTTSMN1; SMN2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4889868 | 0.99 | HRH3 (0.45) | HRH3HTTSMN1; SMN2LMNAMAPT | |
| SCHEMBL4900445 | 0.84 | HRH3 (0.48) | HRH3HTTSMN1; SMN2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4889999 | 0.82 | PI4KA (0.42) | ACHEBCHE | |
| Hydrochloric Acid SCHEMBL4889988 | 0.82 | PI4KA (0.42) | ACHEBCHE | |
| SCHEMBL7154106 | 0.81 | APP (0.40) | SMN1; SMN2KMT2AACHEMEN1BCHE | |
| SCHEMBL7152982 | 0.79 | MAPKAPK2 (0.38) | KMT2AACHEMEN1BCHE | |
| SCHEMBL7152990 | 0.79 | MAPKAPK2 (0.38) | KMT2AACHEMEN1BCHE | |
| Hydrochloric Acid SCHEMBL4898540 | 0.79 | BTK (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | claimed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | claimed |