Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 6/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154804 | 0.73 | RIPK2 (0.33) | RIPK2 | |
| Hydrochloric Acid SCHEMBL4898580 | 0.72 | RIPK2 (0.32) | RIPK2 | |
| SCHEMBL7157428 | 0.70 | MAPK6 (0.39) | MEN1KMT2AMAPKAPK2 | |
| SCHEMBL7157418 | 0.70 | MAPK6 (0.39) | MEN1KMT2AMAPKAPK2 | |
| Hydrochloric Acid SCHEMBL4897810 | 0.69 | MAPK6 (0.38) | MEN1KMT2AMAPKAPK2 | |
| SCHEMBL7154081 | 0.61 | NR4A1 (0.35) | MAPK9MAPK8MAPK10MAPK14MEN1 | |
| SCHEMBL4902038 | 0.61 | MEN1 (0.46) | MEN1KMT2APIK3CAGAAL3MBTL1 | |
| SCHEMBL29130622 | 0.60 | MAPT (0.73) | MEN1KMT2AGAAL3MBTL1NPC1 | |
| SCHEMBL5390852 | 0.58 | MEN1 (0.61) | MEN1KMT2AGAAL3MBTL1CYP1A2 | |
| SCHEMBL11812041 | 0.58 | MAPT (0.81) | MEN1KMT2AGAAL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | disclosed |