Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 8/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 9/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.37 |
| ▸ | CCND1 | P24385 | 3/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895415 | 0.80 | MAP4K4 (0.47) | CDK1CDK2CCNA2CCNA1CDK4 | |
| SCHEMBL4895403 | 0.80 | MAP4K4 (0.47) | CDK1CDK2CCNA2CCNA1CDK4 | |
| SCHEMBL7110928 | 0.79 | CSNK2A1 (0.47) | CDK1PRKCACDK2CCNE1CCNE2 | |
| SCHEMBL7110933 | 0.79 | CSNK2A1 (0.47) | CDK1PRKCACDK2CCNE1CCNE2 | |
| SCHEMBL4889912 | 0.79 | MAPKAPK2 (0.55) | CDK1MAPKAPK2PRKCACDK2CCNE1 | |
| SCHEMBL4889926 | 0.79 | MAPKAPK2 (0.55) | CDK1MAPKAPK2PRKCACDK2CCNE1 | |
| SCHEMBL5891707 | 0.70 | FLT3 (0.53) | CDK1CDK2CCNE1PDGFRA | |
| SCHEMBL5891718 | 0.70 | FLT3 (0.53) | CDK1CDK2CCNE1PDGFRA | |
| Hydrochloric Acid SCHEMBL4892763 | 0.68 | MAPKAPK2 (0.50) | MAPKAPK2KDM4EALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4892770 | 0.68 | MAPKAPK2 (0.50) | MAPKAPK2KDM4EALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | disclosed |