Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 4/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 3/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154151 | 1.00 | PIM1 (0.38) | PIM1MERTKTYRO3AXLCCNB2 | |
| Hydrochloric Acid SCHEMBL4898605 | 0.99 | PIM1 (0.37) | PIM1MERTKTYRO3AXLCCNB2 | |
| Hydrochloric Acid SCHEMBL4898626 | 0.99 | PIM1 (0.37) | PIM1MERTKTYRO3AXLCCNB2 | |
| SCHEMBL7153615 | 0.90 | PIM1 (0.38) | PIM1CCNB2CDK1CCNB1CCNB3 | |
| Hydrochloric Acid SCHEMBL4898599 | 0.89 | PIM1 (0.38) | PIM1CCNB2CDK1CCNB1CCNB3 | |
| Hydrochloric Acid SCHEMBL4898584 | 0.89 | PIM1 (0.38) | PIM1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL7154106 | 0.84 | APP (0.40) | PIM1MERTKTYRO3AXLCCNB2 | |
| SCHEMBL7152982 | 0.81 | MAPKAPK2 (0.38) | PIM1MERTKTYRO3AXLCCNB2 | |
| SCHEMBL7152990 | 0.81 | MAPKAPK2 (0.38) | PIM1MERTKTYRO3AXLCCNB2 | |
| Hydrochloric Acid SCHEMBL4901100 | 0.81 | MAPKAPK2 (0.38) | PIM1MERTKTYRO3AXLCCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | claimed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | claimed |
| EP-1347975-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051843-A1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2002-07-04 | — | — | WO | disclosed |