Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 11/20 | 0.46 |
| ▸ | F2 | P00734 | 5/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154250 | 0.92 | TMPRSS11D (0.47) | FKBP1AF2PRSS1PRSS2PRSS3 | |
| SCHEMBL7155123 | 0.88 | TMPRSS11D (0.47) | FKBP1AF2TMPRSS11D | |
| SCHEMBL7350482 | 0.86 | F2 (0.57) | F2 | |
| SCHEMBL6971414 | 0.86 | F2 (0.57) | F2 | |
| SCHEMBL7346760 | 0.82 | F2 (0.54) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL9073832 | 0.82 | F2 (0.54) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL8820442 | 0.82 | F2 (0.46) | FKBP1AF2PRSS1PRSS2PRSS3 | |
| SCHEMBL7362539 | 0.82 | TACR2 (0.46) | FKBP1AF2PRSS1PRSS2PRSS3 | |
| SCHEMBL7339322 | 0.82 | F2 (0.51) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| Hydrochloric Acid SCHEMBL7106983 | 0.81 | TACR2 (0.46) | FKBP1AF2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534536-B1 | Alkylsulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2003-03-18 | — | — | US | claimed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | claimed |
| US-6534536-B1 | Alkylsulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2003-03-18 | — | — | US | disclosed |
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |