Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7157331 | 1.00 | MAPT (0.46) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7164051 | 0.91 | MAPT (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7164052 | 0.91 | MAPT (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7160735 | 0.87 | MAPT (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7160739 | 0.87 | MAPT (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7157384 | 0.81 | MAPT (0.56) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7160607 | 0.77 | MAPT (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7160603 | 0.77 | MAPT (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL11557673 | 0.71 | KDM4E (0.60) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL13870529 | 0.70 | OPRL1 (0.50) | MAPTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545031-B1 | Carboxyalkenylpyrazolylbenzene derivatives, such as (E)-alpha-((5-(2-((2-carboxyphenyl)methoxy)-4-methoxyphenyl) -1-ethyl-1H-pyrazol-4-yl)methylene)-6-methoxy-1,3-benzodioxole -5-propanoic acid | SMITHKLINE BEECHAM CORPORATION | 2003-04-08 | — | — | US | disclosed |
| EP-0843551-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-02-06 | — | — | EP | disclosed |