Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274960 | 0.86 | TSHR (0.51) | OPRL1ALDH1A1SMN1; SMN2CYP1A2HSP90AA1 | |
| SCHEMBL31123658 | 0.85 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2MAPTHPGDLMNA | |
| SCHEMBL2556246 | 0.84 | ALDH1A1 (0.54) | OPRL1ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL15286510 | 0.84 | ALDH1A1 (0.51) | OPRL1ALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL5989500 | 0.83 | NPC1 (0.56) | OPRL1ALDH1A1SMN1; SMN2HSP90AA1MAPT | |
| SCHEMBL6158837 | 0.83 | ALDH1A1 (0.54) | ALDH1A1CYP1A2HSP90AA1MAPTHPGD | |
| SCHEMBL3134818 | 0.83 | SLC6A3 (0.52) | OPRL1ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL6965429 | 0.82 | MAOB (0.65) | ALDH1A1SMN1; SMN2MAPTLMNAPTPN1 | |
| SCHEMBL13888776 | 0.81 | KDM4E (0.47) | OPRL1ALDH1A1SMN1; SMN2KDM4EPTPN1 | |
| SCHEMBL2801838 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HSP90AA1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524864-B2 | Methods of treating sleep disorders | HYPNION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7482460-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7411069-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7326721-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |