Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 7/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130813 | 0.92 | ADRA1A (0.34) | ADRA1AADRA1BADRA1DHRH1AKT1 | |
| SCHEMBL7130811 | 0.92 | ADRA1A (0.34) | ADRA1AADRA1BADRA1DHRH1AKT1 | |
| SCHEMBL7133092 | 0.85 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1AKT1 | |
| SCHEMBL7133095 | 0.85 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1AKT1 | |
| SCHEMBL7133088 | 0.85 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1AKT1 | |
| SCHEMBL6954879 | 0.82 | ADRA1A (0.35) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL6965577 | 0.81 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1AKT1 | |
| SCHEMBL7968147 | 0.75 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1CHRM4 | |
| SCHEMBL8150536 | 0.75 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1CHRM4 | |
| SCHEMBL8155210 | 0.69 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |