Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9531432 | 0.98 | SIRT2 (0.48) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL2490264 | 0.92 | SIRT2 (0.48) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL8165853 | 0.91 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| Hydrochloric Acid SCHEMBL7988290 | 0.91 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL759 | 0.87 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| Hydrochloric Acid SCHEMBL6926362 | 0.85 | SIRT2 (0.44) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL19865793 | 0.84 | SIRT2 (0.50) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL4382643 | 0.84 | SIRT2 (0.54) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL8794940 | 0.84 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 | |
| SCHEMBL14993551 | 0.84 | SIRT2 (0.49) | SIRT2CYP11B1CYP11B2ENPP2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |